Errol James, Trent University:

"Spartan is an integrated molecular mechanics, semi-empirical and ab initio package with superb graphics, and that makes it great. . .Spartan is a teaching tool of extraordinary power and a research instrument to be reckoned with."
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Molecular Mechanics (SYBYL, MMFF94 & MMFFaq)

Molecular mechanics is presently the only practical method for calculations on very large molecules or for conformational searching on highly flexible molecules. MMFF94, in particular, has proven to be a reliable and fast tool for conformational analysis. There are no atom limits for molecular mechanics calculations.

Both the SYBYL and MMFF94 force fields are supported. SYBYL extends throughout the entire Periodic Table while MMFF94 has been specifically parameterized to reproduce geometries and conformations of organic molecules and biopolymers. Additionally, an MMFFaq option applies an aqueous solvent energy correction to energy data, of special utility in ranking conformers.